Baek Kim Selected Research

SAM Domain and HD Domain-Containing Protein 1

1/2022	Elimination of Aicardi-Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
10/2021	Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
1/2017	A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.

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Baek Kim Research Topics

Disease

27	Infections 01/2022 - 08/2003
23	Neoplasms (Cancer) 10/2021 - 05/2006
8	Breast Neoplasms (Breast Cancer) 05/2021 - 01/2013
5	Triple Negative Breast Neoplasms 01/2022 - 01/2016
4	COVID-19 01/2022 - 07/2020
4	Virus Diseases (Viral Diseases) 01/2020 - 05/2006
3	Acquired Immunodeficiency Syndrome (AIDS) 04/2016 - 01/2013
2	Ataxia Telangiectasia (Louis Bar Syndrome) 08/2021 - 02/2005
2	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 08/2013
2	HIV Infections (HIV Infection) 01/2017 - 06/2012
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2015 - 08/2013
2	Inflammation (Inflammations) 01/2013 - 01/2011
2	Human Influenza (Influenza) 10/2011 - 05/2010
1	Viremia 01/2022
1	Adrenocortical Carcinoma 08/2021
1	Ovarian Epithelial Carcinoma 01/2021
1	Lymphoma (Lymphomas) 01/2021
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2020
1	Genomic Instability 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Flavivirus Infections 01/2019

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 10/2021 - 02/2005
8	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2013
8	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 12/2004
6	NucleotidesIBA 01/2021 - 04/2012
5	EnzymesIBA 10/2021 - 10/2011
5	Interferon Type IIBA 01/2020 - 02/2013
5	Pharmaceutical PreparationsIBA 11/2019 - 01/2016
4	InterferonsIBA 01/2022 - 12/2012
3	SAM Domain and HD Domain-Containing Protein 1IBA 01/2022 - 01/2017
3	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 08/2021 - 01/2012
3	NucleosidesIBA 04/2021 - 01/2017
3	RNA (Ribonucleic Acid)IBA 01/2021 - 08/2014
3	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2017 - 04/2005
3	Viral DNAIBA 10/2012 - 05/2006
2	Histidine (L-Histidine)FDA Link 10/2021 - 12/2020
2	Aspartic Acid (Aspartate)FDA Link 10/2021 - 12/2020
2	XenobioticsIBA 01/2021 - 01/2013
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2021 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 01/2019
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2021 - 01/2013
2	Small Interfering RNA (siRNA)IBA 01/2021 - 01/2014
2	LipopolysaccharidesIBA 01/2020 - 01/2012
2	multidrug resistance-associated protein 1IBA 09/2015 - 01/2013
2	GinsenosidesIBA 08/2014 - 01/2013
2	triphosphoric acid (triphosphate)IBA 12/2012 - 10/2012
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 02/2012 - 08/2003
2	Phosphotransferases (Kinase)IBA 01/2012 - 01/2008
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2022
1	Viral ProteinsIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 10/2021
1	baicaleinIBA 04/2021
1	baicalinIBA 04/2021
1	remdesivirIBA 01/2021
1	GS-441524IBA 01/2021
1	integrin alpha7beta1IBA 01/2021
1	olaparibIBA 01/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021
1	Liver X ReceptorsIBA 01/2021
1	CholesterolIBA 01/2021
1	HydroxycholesterolsIBA 01/2021
1	LigandsIBA 01/2021
1	NADP (NADPH)IBA 01/2021
1	ProdrugsIBA 01/2021
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2021
1	TetraspaninsIBA 08/2020
1	DeoxycytidineIBA 01/2020
1	Long Noncoding RNAIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	IonophoresIBA 01/2020
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2020
1	dihydrouracilIBA 01/2020
1	salinomycinIBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	Untranslated RNA (Noncoding RNA)IBA 01/2020
1	dihydropyrimidinaseIBA 01/2020
1	dihydromyricetinIBA 01/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020
1	pyrimidineIBA 01/2020
1	ZincIBA 01/2020
1	Adenylosuccinate LyaseIBA 11/2019
1	Mixed Function Oxygenases (Monooxygenases)IBA 11/2019
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 11/2019
1	Thymidylate SynthaseIBA 11/2019
1	Niclosamide FDA Link 01/2019
1	AnthracyclinesIBA 12/2018
1	Epirubicin (Ellence)FDA LinkGeneric 12/2018
1	Cyclin A2IBA 01/2018

Therapy/Procedure

6	Drug Therapy (Chemotherapy) 01/2022 - 01/2013
6	Therapeutics 01/2021 - 12/2018
3	Neoadjuvant Therapy 12/2018 - 01/2013
1	Chemoprevention 05/2021
1	Mammaplasty (Breast Reconstruction) 12/2020
1	Critical Care (Surgical Intensive Care) 07/2020
1	Radiotherapy 01/2020
1	Aftercare (After-Treatment) 12/2018
1	Adjuvant Chemotherapy 12/2018